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Binding Hot Spots and Amantadine Orientation in the Influenza A Virus M2 Proton Channel

Structures of truncated versions of the influenza A virus M2 proton channel have been determined recently by x-ray crystallography in the open conformation of the channel, and by NMR in the closed state. The structures differ in the position of the bound inhibitors. The x-ray structure shows a singl...

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Библиографические подробности
Главные авторы: Chuang, Gwo-Yu, Kozakov, Dima, Brenke, Ryan, Beglov, Dmitri, Guarnieri, Frank, Vajda, Sandor
Формат: Artigo
Язык:Inglês
Опубликовано: The Biophysical Society 2009
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776279/
https://ncbi.nlm.nih.gov/pubmed/19917240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.09.004
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