Structural conservation of druggable hot spots in protein–protein interfaces

Despite the growing number of examples of small-molecule inhibitors that disrupt protein–protein interactions (PPIs), the origin of druggability of such targets is poorly understood. To identify druggable sites in protein–protein interfaces we combine computational solvent mapping, which explores th...

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Bibliografiske detaljer
Main Authors: Kozakov, Dima, Hall, David R., Chuang, Gwo-Yu, Cencic, Regina, Brenke, Ryan, Grove, Laurie E., Beglov, Dmitri, Pelletier, Jerry, Whitty, Adrian, Vajda, Sandor
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158149/
https://ncbi.nlm.nih.gov/pubmed/21808046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101835108
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