Identification of β-strand mediated protein–protein interaction inhibitors using ligand-directed fragment ligation

β-Strand mediated protein–protein interactions (PPIs) represent underexploited targets for chemical probe development despite representing a significant proportion of known and therapeutically relevant PPI targets. β-Strand mimicry is challenging given that both amino acid side-chains and backbone h...

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Detaylı Bibliyografya
Yayımlandı:Chem Sci
Asıl Yazarlar: Hegedüs, Zsófia, Hóbor, Fruzsina, Shoemark, Deborah K., Celis, Sergio, Lian, Lu-Yun, Trinh, Chi H., Sessions, Richard B., Edwards, Thomas A., Wilson, Andrew J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Royal Society of Chemistry 2021
Konular:
Chemistry
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179271/
https://ncbi.nlm.nih.gov/pubmed/34163995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc05694d
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