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Identification of β-strand mediated protein–protein interaction inhibitors using ligand-directed fragment ligation
β-Strand mediated protein–protein interactions (PPIs) represent underexploited targets for chemical probe development despite representing a significant proportion of known and therapeutically relevant PPI targets. β-Strand mimicry is challenging given that both amino acid side-chains and backbone h...
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| Publicado no: | Chem Sci |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society of Chemistry
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8179271/ https://ncbi.nlm.nih.gov/pubmed/34163995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc05694d |
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