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BIM-46174 fragments as potential ligands of G proteins
The 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine derivative BIM-46174 has received attention as Gα(q) inhibitor. We conducted structural reductions to monocyclic and bicyclic substructures to explore the chemical space of BIM fragments and to gain insights into the pharmacophore of BIM-type Gα(q) inhibi...
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| Publicado no: | Medchemcomm |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7053702/ https://ncbi.nlm.nih.gov/pubmed/32180917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00269c |
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