Stapled Peptides as HIF‐1α/p300 Inhibitors: Helicity Enhancement in the Bound State Increases Inhibitory Potency

Protein–protein interactions (PPIs) control virtually all cellular processes and have thus emerged as potential targets for development of molecular therapeutics. Peptide‐based inhibitors of PPIs are attractive given that they offer recognition potency and selectivity features that are ideal for fun...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Hetherington, Kristina, Hegedus, Zsofia, Edwards, Thomas A., Sessions, Richard B., Nelson, Adam, Wilson, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318359/
https://ncbi.nlm.nih.gov/pubmed/32307728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202000417
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