Stapled Peptides as HIF‐1α/p300 Inhibitors: Helicity Enhancement in the Bound State Increases Inhibitory Potency

Protein–protein interactions (PPIs) control virtually all cellular processes and have thus emerged as potential targets for development of molecular therapeutics. Peptide‐based inhibitors of PPIs are attractive given that they offer recognition potency and selectivity features that are ideal for fun...

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Detaylı Bibliyografya
Yayımlandı:Chemistry
Asıl Yazarlar: Hetherington, Kristina, Hegedus, Zsofia, Edwards, Thomas A., Sessions, Richard B., Nelson, Adam, Wilson, Andrew J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2020
Konular:
Full Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318359/
https://ncbi.nlm.nih.gov/pubmed/32307728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202000417
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