Stapled Peptides as HIF‐1α/p300 Inhibitors: Helicity Enhancement in the Bound State Increases Inhibitory Potency

Protein–protein interactions (PPIs) control virtually all cellular processes and have thus emerged as potential targets for development of molecular therapeutics. Peptide‐based inhibitors of PPIs are attractive given that they offer recognition potency and selectivity features that are ideal for fun...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Chemistry
Autori principali: Hetherington, Kristina, Hegedus, Zsofia, Edwards, Thomas A., Sessions, Richard B., Nelson, Adam, Wilson, Andrew J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Full Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318359/
https://ncbi.nlm.nih.gov/pubmed/32307728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202000417
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi