ERK signaling mediates resistance to immunomodulatory drugs in the bone marrow microenvironment

Immunomodulatory drugs (IMiDs) have markedly improved patient outcome in multiple myeloma (MM); however, resistance to IMiDs commonly underlies relapse of disease. Here, we identify that tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) knockdown (KD)/knockout (KO) in MM cells mediate...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Liu, Jiye, Hideshima, Teru, Xing, Lijie, Wang, Su, Zhou, Wenrong, Samur, Mehmet K., Sewastianik, Tomasz, Ogiya, Daisuke, An, Gang, Gao, Shaobing, Yang, Li, Ji, Tong, Bianchi, Giada, Wen, Kenneth, Tai, Yu-Tzu, Munshi, Nikhil, Richardson, Paul, Carrasco, Ruben, Cang, Yong, Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8177702/
https://ncbi.nlm.nih.gov/pubmed/34088671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg2697
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