The JAK-STAT pathway regulates CD38 on myeloma cells in the bone marrow microenvironment: therapeutic implications

Anti-CD38 monoclonal antibody (MoAb) treatments including daratumumab (DARA) are effective therapies for both newly diagnosed and relapsed multiple myeloma (MM). In this study, we examined the soluble factors that modulate CD38 expression and are associated with sensitivity to DARA-mediated antibody...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Ogiya, Daisuke, Liu, Jiye, Ohguchi, Hiroto, Kurata, Keiji, Samur, Mehmet K., Tai, Yu-Tzu, Adamia, Sophia, Ando, Kiyoshi, Hideshima, Teru, Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7702477/
https://ncbi.nlm.nih.gov/pubmed/32844992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019004332
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