Protein Arginine Methyltransferase 5 (PRMT5) has prognostic relevance and is a druggable target in Multiple Myeloma

Arginine methyltransferases critically regulate cellular homeostasis by modulating the functional outcome of their substrates. The protein arginine methyltransferase 5 (PRMT5) is an enzyme involved in growth and survival pathways promoting tumorigenesis. However, little is known about the biologic f...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Gullà, Annamaria, Hideshima, Teru, Bianchi, Giada, Fulciniti, Mariateresa, Samur, Mehmet Kemal, Qi, Jun, Tai, Yu-Tzu, Harada, Takeshi, Morelli, Eugenio, Amodio, Nicola, Carrasco, Ruben, Tagliaferri, Pierosandro, Munshi, Nikhil C., Tassone, Pierfrancesco, Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871539/
https://ncbi.nlm.nih.gov/pubmed/29158558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.334
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