A 13 mer LNA-i-miR-221 inhibitor restores drug-sensitivity in melphalan-refractory multiple myeloma cells

PURPOSE: The onset of drug-resistance is a major cause of treatment failure in multiple myeloma (MM). While increasing evidence is defining the role of microRNAs in mediating drug-resistance, their potential activity as drug-sensitizing agents has not yet been investigated in MM. EXPERIMENTAL DESIGN...

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Опубликовано в: :Clin Cancer Res
Главные авторы: Gullà, Annamaria, Di Martino, Maria Teresa, Cantafio, Maria Eugenia Gallo, Morelli, Eugenio, Amodio, Nicola, Botta, Cirino, Pitari, Maria Rita, Lio, Santo Giovanni, Britti, Domenico, Stamato, Maria Angelica, Hideshima, Teru, Munshi, Nikhil C., Anderson, Kenneth C., Tagliaferri, Pierosandro, Tassone, Pierfrancesco
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775414/
https://ncbi.nlm.nih.gov/pubmed/26527748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0489
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