A 13 mer LNA-i-miR-221 inhibitor restores drug-sensitivity in melphalan-refractory multiple myeloma cells

PURPOSE: The onset of drug-resistance is a major cause of treatment failure in multiple myeloma (MM). While increasing evidence is defining the role of microRNAs in mediating drug-resistance, their potential activity as drug-sensitizing agents has not yet been investigated in MM. EXPERIMENTAL DESIGN...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Clin Cancer Res
Egile Nagusiak: Gullà, Annamaria, Di Martino, Maria Teresa, Cantafio, Maria Eugenia Gallo, Morelli, Eugenio, Amodio, Nicola, Botta, Cirino, Pitari, Maria Rita, Lio, Santo Giovanni, Britti, Domenico, Stamato, Maria Angelica, Hideshima, Teru, Munshi, Nikhil C., Anderson, Kenneth C., Tagliaferri, Pierosandro, Tassone, Pierfrancesco
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775414/
https://ncbi.nlm.nih.gov/pubmed/26527748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0489
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