A 13 mer LNA-i-miR-221 inhibitor restores drug-sensitivity in melphalan-refractory multiple myeloma cells

PURPOSE: The onset of drug-resistance is a major cause of treatment failure in multiple myeloma (MM). While increasing evidence is defining the role of microRNAs in mediating drug-resistance, their potential activity as drug-sensitizing agents has not yet been investigated in MM. EXPERIMENTAL DESIGN...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Clin Cancer Res
Main Authors: Gullà, Annamaria, Di Martino, Maria Teresa, Cantafio, Maria Eugenia Gallo, Morelli, Eugenio, Amodio, Nicola, Botta, Cirino, Pitari, Maria Rita, Lio, Santo Giovanni, Britti, Domenico, Stamato, Maria Angelica, Hideshima, Teru, Munshi, Nikhil C., Anderson, Kenneth C., Tagliaferri, Pierosandro, Tassone, Pierfrancesco
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775414/
https://ncbi.nlm.nih.gov/pubmed/26527748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0489
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