In Vitro and In Vivo Activity of a Novel Locked Nucleic Acid (LNA)-Inhibitor-miR-221 against Multiple Myeloma Cells

BACKGROUND & AIM: The miR-221/222 cluster is upregulated in malignant plasma cells from multiple myeloma (MM) patients harboring the t(4;14) translocation. We previously reported that silencing of miR-221/222 by an antisense oligonucleotide induces anti-MM activity and upregulates canonical miR-...

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Detaylı Bibliyografya
Asıl Yazarlar: Di Martino, Maria Teresa, Gullà, Annamaria, Gallo Cantafio, Maria Eugenia, Altomare, Emanuela, Amodio, Nicola, Leone, Emanuela, Morelli, Eugenio, Lio, Santo Giovanni, Caracciolo, Daniele, Rossi, Marco, Frandsen, Niels M., Tagliaferri, Pierosandro, Tassone, Pierfrancesco
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931823/
https://ncbi.nlm.nih.gov/pubmed/24586944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089659
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