In Vitro and In Vivo Activity of a Novel Locked Nucleic Acid (LNA)-Inhibitor-miR-221 against Multiple Myeloma Cells

BACKGROUND & AIM: The miR-221/222 cluster is upregulated in malignant plasma cells from multiple myeloma (MM) patients harboring the t(4;14) translocation. We previously reported that silencing of miR-221/222 by an antisense oligonucleotide induces anti-MM activity and upregulates canonical miR-...

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Main Authors: Di Martino, Maria Teresa, Gullà, Annamaria, Gallo Cantafio, Maria Eugenia, Altomare, Emanuela, Amodio, Nicola, Leone, Emanuela, Morelli, Eugenio, Lio, Santo Giovanni, Caracciolo, Daniele, Rossi, Marco, Frandsen, Niels M., Tagliaferri, Pierosandro, Tassone, Pierfrancesco
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931823/
https://ncbi.nlm.nih.gov/pubmed/24586944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089659
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