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Allometric Scaling Approaches for Predicting Human Pharmacokinetic of a Locked Nucleic Acid Oligonucleotide Targeting Cancer-Associated miR-221

LNA-i-miR-221 is a novel phosphorothioate backbone 13-mer locked nucleic acid oligonucleotide-targeting microRNA-221 designed for the treatment of human malignancies. To understand the pharmacokinetic properties of this new agent, including unbound/total clearance, we investigated the LNA-i-miR-221...

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Bibliografski detalji
Izdano u:Cancers (Basel)
Glavni autori: Di Martino, Maria Teresa, Arbitrio, Mariamena, Fonsi, Massimiliano, Erratico, Claudio Alberto, Scionti, Francesca, Caracciolo, Daniele, Tagliaferri, Pierosandro, Tassone, Pierfrancesco
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017297/
https://ncbi.nlm.nih.gov/pubmed/31861748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12010027
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