Dose-Finding Study and Pharmacokinetics Profile of the Novel 13-Mer Antisense miR-221 Inhibitor in Sprague-Dawley Rats

miR-221 is overexpressed in several malignancies where it promotes tumor growth and survival by interfering with gene transcripts, including p27Kip1, PUMA, PTEN, and p57Kip2. We previously demonstrated that a novel 13-mer miR-221 inhibitor (locked nucleic acid [LNA]-i-miR-221) exerts antitumor activ...

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Опубликовано в: :Mol Ther Nucleic Acids
Главные авторы: Di Martino, Maria Teresa, Arbitrio, Mariamena, Caracciolo, Daniele, Scionti, Francesca, Tagliaferri, Pierosandro, Tassone, Pierfrancesco
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Gene & Cell Therapy 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058714/
https://ncbi.nlm.nih.gov/pubmed/32146420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.01.036
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