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27-plex Tandem Mass Tag Mass Spectrometry for Profiling Brain Proteome in Alzheimer's Disease

Multiplexed isobaric labeling methods, such as Tandem Mass Tags (TMT), remarkably improve the throughput of quantitative mass spectrometry. Here we present a 27-plex TMT method coupled with two-dimensional liquid chromatography (LC/LC) for extensive peptide fractionation and high-resolution tandem m...

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Dades bibliogràfiques
Publicat a:Anal Chem
Autors principals: Wang, Zhen, Yu, Kaiwen, Tan, Haiyan, Wu, Zhiping, Cho, Ji-Hoon, Han, Xian, Sun, Huan, Beach, Thomas G., Peng, Junmin
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8176402/
https://ncbi.nlm.nih.gov/pubmed/32343560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.0c00655
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