Crowdsourced mapping of unexplored target space of kinase inhibitors

Despite decades of intensive search for compounds that modulate the activity of particular protein targets, a large proportion of the human kinome remains as yet undrugged. Effective approaches are therefore required to map the massive space of unexplored compound–kinase interactions for novel and p...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Cichońska, Anna, Ravikumar, Balaguru, Allaway, Robert J., Wan, Fangping, Park, Sungjoon, Isayev, Olexandr, Li, Shuya, Mason, Michael, Lamb, Andrew, Tanoli, Ziaurrehman, Jeon, Minji, Kim, Sunkyu, Popova, Mariya, Capuzzi, Stephen, Zeng, Jianyang, Dang, Kristen, Koytiger, Gregory, Kang, Jaewoo, Wells, Carrow I., Willson, Timothy M., Oprea, Tudor I., Schlessinger, Avner, Drewry, David H., Stolovitzky, Gustavo, Wennerberg, Krister, Guinney, Justin, Aittokallio, Tero
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2021
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175708/
https://ncbi.nlm.nih.gov/pubmed/34083538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23165-1
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