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Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors

Due to relatively high costs and labor required for experimental profiling of the full target space of chemical compounds, various machine learning models have been proposed as cost-effective means to advance this process in terms of predicting the most potent compound-target interactions for subseq...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Cichonska, Anna, Ravikumar, Balaguru, Parri, Elina, Timonen, Sanna, Pahikkala, Tapio, Airola, Antti, Wennerberg, Krister, Rousu, Juho, Aittokallio, Tero
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560747/
https://ncbi.nlm.nih.gov/pubmed/28787438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005678
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