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Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors

Due to relatively high costs and labor required for experimental profiling of the full target space of chemical compounds, various machine learning models have been proposed as cost-effective means to advance this process in terms of predicting the most potent compound-target interactions for subseq...

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Podrobná bibliografie
Vydáno v:PLoS Comput Biol
Hlavní autoři: Cichonska, Anna, Ravikumar, Balaguru, Parri, Elina, Timonen, Sanna, Pahikkala, Tapio, Airola, Antti, Wennerberg, Krister, Rousu, Juho, Aittokallio, Tero
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560747/
https://ncbi.nlm.nih.gov/pubmed/28787438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005678
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