Crowdsourced mapping of unexplored target space of kinase inhibitors

Despite decades of intensive search for compounds that modulate the activity of particular protein targets, a large proportion of the human kinome remains as yet undrugged. Effective approaches are therefore required to map the massive space of unexplored compound–kinase interactions for novel and p...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Cichońska, Anna, Ravikumar, Balaguru, Allaway, Robert J., Wan, Fangping, Park, Sungjoon, Isayev, Olexandr, Li, Shuya, Mason, Michael, Lamb, Andrew, Tanoli, Ziaurrehman, Jeon, Minji, Kim, Sunkyu, Popova, Mariya, Capuzzi, Stephen, Zeng, Jianyang, Dang, Kristen, Koytiger, Gregory, Kang, Jaewoo, Wells, Carrow I., Willson, Timothy M., Oprea, Tudor I., Schlessinger, Avner, Drewry, David H., Stolovitzky, Gustavo, Wennerberg, Krister, Guinney, Justin, Aittokallio, Tero
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175708/
https://ncbi.nlm.nih.gov/pubmed/34083538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23165-1
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