Crowdsourced mapping of unexplored target space of kinase inhibitors

Despite decades of intensive search for compounds that modulate the activity of particular protein targets, a large proportion of the human kinome remains as yet undrugged. Effective approaches are therefore required to map the massive space of unexplored compound–kinase interactions for novel and p...

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Publicado en:Nat Commun
Autores principales: Cichońska, Anna, Ravikumar, Balaguru, Allaway, Robert J., Wan, Fangping, Park, Sungjoon, Isayev, Olexandr, Li, Shuya, Mason, Michael, Lamb, Andrew, Tanoli, Ziaurrehman, Jeon, Minji, Kim, Sunkyu, Popova, Mariya, Capuzzi, Stephen, Zeng, Jianyang, Dang, Kristen, Koytiger, Gregory, Kang, Jaewoo, Wells, Carrow I., Willson, Timothy M., Oprea, Tudor I., Schlessinger, Avner, Drewry, David H., Stolovitzky, Gustavo, Wennerberg, Krister, Guinney, Justin, Aittokallio, Tero
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175708/
https://ncbi.nlm.nih.gov/pubmed/34083538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23165-1
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