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Synthesis and biological evaluation of (2S,2′S)-lomaiviticin A.
(–)-Lomaiviticin A (1) is a genotoxic C(2)-symmetric metabolite that arises from the formal dimerization of two bis(glycosylated) diazotetrahydrobenzo[b]fluorenes. Here we present a synthesis of the monomer 17 and its coupling to form (2S,2’S)-lomaiviticin A (4), an unnatural diastereomer of 1. (2S,...
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| Published in: | J Am Chem Soc |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8174553/ https://ncbi.nlm.nih.gov/pubmed/33410680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c11960 |
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