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Synergistic potentiation of (−)-lomaiviticin A cytotoxicity by the ATR inhibitor VE-821
(−)-Lomaiviticin A (1) is a cytotoxic bacterial metabolite that induces double-strand breaks in DNA. Here we show that the cytotoxicity of (−)-lomaiviticin A (1) is synergistically potentiated in the presence of VE-821 (7), an inhibitor of ataxia telangiectasia and Rad3-related protein (ATR). While...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4899226/ https://ncbi.nlm.nih.gov/pubmed/27177826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.04.090 |
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