Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R(p)- and S(p)-dNTPαS Diastereomers

[Image: see text] SAMHD1 is a fundamental regulator of cellular dNTPs that catalyzes their hydrolysis into 2′-deoxynucleoside and triphosphate, restricting the replication of viruses, including HIV-1, in CD4(+) myeloid lineage and resting T-cells. SAMHD1 mutations are associated with the autoimmune...

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Détails bibliographiques
Publié dans:Biochemistry
Auteurs principaux: Morris, Elizabeth R., Kunzelmann, Simone, Caswell, Sarah J., Purkiss, Andrew G., Kelly, Geoff, Taylor, Ian A.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2021
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8173608/
https://ncbi.nlm.nih.gov/pubmed/33988981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00944
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