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Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R(p)- and S(p)-dNTPαS Diastereomers
[Image: see text] SAMHD1 is a fundamental regulator of cellular dNTPs that catalyzes their hydrolysis into 2′-deoxynucleoside and triphosphate, restricting the replication of viruses, including HIV-1, in CD4(+) myeloid lineage and resting T-cells. SAMHD1 mutations are associated with the autoimmune...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Biochemistry |
|---|---|
| Prif Awduron: | , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American
Chemical Society
2021
|
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8173608/ https://ncbi.nlm.nih.gov/pubmed/33988981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00944 |
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