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Flavin-dependent halogenases catalyze enantioselective olefin halocyclization

Halocyclization of alkenes is a powerful bond-forming tool in synthetic organic chemistry and a key step in natural product biosynthesis, but catalyzing halocyclization with high enantioselectivity remains a challenging task. Identifying suitable enzymes that catalyze enantioselective halocyclizatio...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Mondal, Dibyendu, Fisher, Brian F., Jiang, Yuhua, Lewis, Jared C.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169660/
https://ncbi.nlm.nih.gov/pubmed/34075034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23503-3
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