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A flavin-dependent halogenase catalyzes the chlorination step in the biosynthesis of Dictyostelium differentiation-inducing factor 1

Differentiation-inducing factor 1 (DIF-1) is a polyketide-derived morphogen which drives stalk cell formation in the developmental cycle of Dictyostelium discoideum. Previous experiments demonstrated that the biosynthetic pathway proceeds via dichlorination of the precursor molecule THPH, but the en...

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Hlavní autoři: Neumann, Christopher S., Walsh, Christopher T., Kay, Robert R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851905/
https://ncbi.nlm.nih.gov/pubmed/20231486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001681107
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