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Specific chlorination of isoquinolines by a fungal flavin-dependent halogenase
Rdc2 is the first flavin-dependent halogenase identified from fungi. Based on the reported structure of the bacterial halogenase CmlS, we have built a homology model for Rdc2. The model suggests an open substrate binding site that is capable of binding the natural substrate, monocillin II, and possi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557752/ https://ncbi.nlm.nih.gov/pubmed/23312946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.12.038 |
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