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Glucagon transiently stimulates mTORC1 by activation of an EPAC/Rap1 signaling axis

Activation of the protein kinase mechanistic target of rapamycin (mTOR) in both complexes 1 and 2 (mTORC1/2) in the liver is repressed during fasting and rapidly stimulated in response to a meal. The effect of feeding on hepatic mTORC1/2 is attributed to an increase in plasma levels of nutrients, su...

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Detalhes bibliográficos
Publicado no:Cell Signal
Main Authors: Sunilkumar, Siddharth, Kimball, Scot R., Dennis, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169602/
https://ncbi.nlm.nih.gov/pubmed/33872697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2021.110010
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