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Purifying selection on noncoding deletions of human regulatory loci detected using their cellular pleiotropy
Genomic deletions provide a powerful loss-of-function model in noncoding regions to assess the role of purifying selection on genetic variation. Regulatory element function is characterized by nonuniform tissue and cell type activity, necessarily linking the study of fitness consequences from regula...
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| Publicado no: | Genome Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8168579/ https://ncbi.nlm.nih.gov/pubmed/33963077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.275263.121 |
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