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Widespread purifying selection at polymorphic sites in human protein-coding loci
Estimation of gene diversity (heterozygosity) at 1,442 single-nucleotide polymorphism (SNP) loci in an ethnically diverse sample of humans revealed consistently reduced gene diversities at SNP loci causing amino acid changes, particularly those causing amino acid changes predicted to be disruptive t...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2003
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC307640/ https://ncbi.nlm.nih.gov/pubmed/14660790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2536718100 |
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