Widespread purifying selection at polymorphic sites in human protein-coding loci

Estimation of gene diversity (heterozygosity) at 1,442 single-nucleotide polymorphism (SNP) loci in an ethnically diverse sample of humans revealed consistently reduced gene diversities at SNP loci causing amino acid changes, particularly those causing amino acid changes predicted to be disruptive t...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Hughes, Austin L., Packer, Bernice, Welch, Robert, Bergen, Andrew W., Chanock, Stephen J., Yeager, Meredith
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307640/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14660790/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2536718100
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker