Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy

Traditional genome-wide scans for positive selection have mainly uncovered selective sweeps associated with monogenic traits. While selection on quantitative traits is much more common, very few signals have been detected because of their polygenic nature. We searched for positive selection signals...

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Udgivet i:PLoS Genet
Main Authors: Byars, Sean G., Huang, Qin Qin, Gray, Lesley-Ann, Bakshi, Andrew, Ripatti, Samuli, Abraham, Gad, Stearns, Stephen C., Inouye, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5480811/
https://ncbi.nlm.nih.gov/pubmed/28640878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006328
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