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Widely distributed noncoding purifying selection in the human genome

It is widely assumed that human noncoding sequences comprise a substantial reservoir for functional variants impacting gene regulation and other chromosomal processes. Evolutionarily conserved noncoding sequences (CNSs) in the human genome have attracted considerable attention for their potential to...

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Detalhes bibliográficos
Main Authors: Asthana, Saurabh, Noble, William S., Kryukov, Gregory, Grant, Charles E., Sunyaev, Shamil, Stamatoyannopoulos, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1941483/
https://ncbi.nlm.nih.gov/pubmed/17640883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705140104
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