Whole exome sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target

Patients diagnosed with anaplastic large cell lymphoma (ALCL) are still treated with toxic multi-agent chemotherapy and as many as 25-50% of patients relapse. To understand disease pathology and to uncover novel targets for therapy, we performed whole-exome sequencing of anaplastic lymphoma kinase (...

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Опубликовано в: :Haematologica
Главные авторы: Larose, Hugo, Prokoph, Nina, Matthews, Jamie D., Schlederer, Michaela, Högler, Sandra, Alsulami, Ali F., Ducray, Stephen P., Nuglozeh, Edem, Fazaludeen, Mohammad Feroze, Elmouna, Ahmed, Ceccon, Monica, Mologni, Luca, Gambacorti-Passerini, Carlo, Hoefler, Gerald, Lobello, Cosimo, Pospisilova, Sarka, Janikova, Andrea, Woessmann, Wilhelm, Welk, Christine Damm-, Zimmermann, Mar tin, Fedorova, Alina, Malone, Andrea, Smith, Owen, Wasik, Mariusz, Inghirami, Giorgio, Lamant, Laurence, Blundell, Tom L., Klapper, Wolfram, Merkel, Olaf, Burke, G. A. Amos, Mian, Shahid, Ashankyty, Ibraheem, Kenner, Lukas, Turner, Suzanne D.
Формат: Artigo
Язык:Inglês
Опубликовано: Fondazione Ferrata Storti 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168516/
https://ncbi.nlm.nih.gov/pubmed/32327503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.238766
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