Whole exome sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target

Patients diagnosed with anaplastic large cell lymphoma (ALCL) are still treated with toxic multi-agent chemotherapy and as many as 25-50% of patients relapse. To understand disease pathology and to uncover novel targets for therapy, we performed whole-exome sequencing of anaplastic lymphoma kinase (...

সম্পূর্ণ বিবরণ

সংরক্ষণ করুন:
গ্রন্থ-পঞ্জীর বিবরন
প্রকাশিত:Haematologica
প্রধান লেখক: Larose, Hugo, Prokoph, Nina, Matthews, Jamie D., Schlederer, Michaela, Högler, Sandra, Alsulami, Ali F., Ducray, Stephen P., Nuglozeh, Edem, Fazaludeen, Mohammad Feroze, Elmouna, Ahmed, Ceccon, Monica, Mologni, Luca, Gambacorti-Passerini, Carlo, Hoefler, Gerald, Lobello, Cosimo, Pospisilova, Sarka, Janikova, Andrea, Woessmann, Wilhelm, Welk, Christine Damm-, Zimmermann, Mar tin, Fedorova, Alina, Malone, Andrea, Smith, Owen, Wasik, Mariusz, Inghirami, Giorgio, Lamant, Laurence, Blundell, Tom L., Klapper, Wolfram, Merkel, Olaf, Burke, G. A. Amos, Mian, Shahid, Ashankyty, Ibraheem, Kenner, Lukas, Turner, Suzanne D.
বিন্যাস: Artigo
ভাষা:Inglês
প্রকাশিত: Fondazione Ferrata Storti 2020
বিষয়গুলি:
Article
অনলাইন ব্যবহার করুন:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168516/
https://ncbi.nlm.nih.gov/pubmed/32327503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.238766
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