Whole exome sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target

Patients diagnosed with anaplastic large cell lymphoma (ALCL) are still treated with toxic multi-agent chemotherapy and as many as 25-50% of patients relapse. To understand disease pathology and to uncover novel targets for therapy, we performed whole-exome sequencing of anaplastic lymphoma kinase (...

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Publicado en:Haematologica
Autores principales: Larose, Hugo, Prokoph, Nina, Matthews, Jamie D., Schlederer, Michaela, Högler, Sandra, Alsulami, Ali F., Ducray, Stephen P., Nuglozeh, Edem, Fazaludeen, Mohammad Feroze, Elmouna, Ahmed, Ceccon, Monica, Mologni, Luca, Gambacorti-Passerini, Carlo, Hoefler, Gerald, Lobello, Cosimo, Pospisilova, Sarka, Janikova, Andrea, Woessmann, Wilhelm, Welk, Christine Damm-, Zimmermann, Mar tin, Fedorova, Alina, Malone, Andrea, Smith, Owen, Wasik, Mariusz, Inghirami, Giorgio, Lamant, Laurence, Blundell, Tom L., Klapper, Wolfram, Merkel, Olaf, Burke, G. A. Amos, Mian, Shahid, Ashankyty, Ibraheem, Kenner, Lukas, Turner, Suzanne D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Fondazione Ferrata Storti 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168516/
https://ncbi.nlm.nih.gov/pubmed/32327503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.238766
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