HGG-39. ALTERNATIVE SPLICING OF NEUROFIBROMIN 1 IS ASSOCIATED WITH ELEVATED MAPK ACTIVITY AND POOR PROGNOSIS IN HIGH-GRADE GLIOMA

Despite a good understanding of the coding mutations underlying high-grade gliomas (HGG), their prognosis remains poor. We sought to characterize their transcriptional alterations and how this contributes to pathogenesis. We analyzed a large cohort of pediatric HGG (pHGG) by DNA sequencing (n=79) an...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Siddaway, Robert, Milos, Scott, Vadivel, Arun, Dobson, Tara, Swaminathan, Jyothishmathi, Ryall, Scott, Pajovic, Sanja, Nazarian, Javad, Becher, Oren, Brudno, Michael, Ramani, Arun, Gopalakrishnan, Vidya, Hawkins, Cynthia
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
High Grade Gliomas
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168180/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.103
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados