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HGG-18. ALTERNATIVE SPLICING OF NEUROFIBROMIN 1 IS ASSOCIATED WITH ELEVATED MAPK ACTIVITY AND POOR PROGNOSIS IN HIGH-GRADE GLIOMA
Pediatric high-grade gliomas (pHGG) are invasive tumors with poor prognosis. In particular, diffuse intrinsic pontine glioma (DIPG), arising in the brainstem, is incurable and the leading cause of brain-tumor death in children. Previous genomic studies have uncovered many driving mutations of pHGG,...
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| Publicado no: | Neuro Oncol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6477264/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.112 |
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