HGG-18. ALTERNATIVE SPLICING OF NEUROFIBROMIN 1 IS ASSOCIATED WITH ELEVATED MAPK ACTIVITY AND POOR PROGNOSIS IN HIGH-GRADE GLIOMA

Pediatric high-grade gliomas (pHGG) are invasive tumors with poor prognosis. In particular, diffuse intrinsic pontine glioma (DIPG), arising in the brainstem, is incurable and the leading cause of brain-tumor death in children. Previous genomic studies have uncovered many driving mutations of pHGG,...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Siddaway, Robert, Milos, Scott, Ramani, Arun, Yu, Man, Ryall, Scott, Li, Christopher, Brudno, Michael, Hawkins, Cynthia
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
High Grade Glioma
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477264/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.112
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