USP7 limits CDK1 activity throughout the cell cycle

Chemical inhibitors of the deubiquitinase USP7 are currently being developed as anticancer agents based on their capacity to stabilize P53. Regardless of this activity, USP7 inhibitors also generate DNA damage in a p53‐independent manner. However, the mechanism of this genotoxicity and its contribut...

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Bibliographic Details
Published in:EMBO J
Main Authors: Galarreta, Antonio, Valledor, Pablo, Ubieto‐Capella, Patricia, Lafarga, Vanesa, Zarzuela, Eduardo, Muñoz, Javier, Malumbres, Marcos, Lecona, Emilio, Fernandez‐Capetillo, Oscar
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167359/
https://ncbi.nlm.nih.gov/pubmed/33856059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899692
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