USP7 limits CDK1 activity throughout the cell cycle

Chemical inhibitors of the deubiquitinase USP7 are currently being developed as anticancer agents based on their capacity to stabilize P53. Regardless of this activity, USP7 inhibitors also generate DNA damage in a p53‐independent manner. However, the mechanism of this genotoxicity and its contribut...

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Detaylı Bibliyografya
Yayımlandı:EMBO J
Asıl Yazarlar: Galarreta, Antonio, Valledor, Pablo, Ubieto‐Capella, Patricia, Lafarga, Vanesa, Zarzuela, Eduardo, Muñoz, Javier, Malumbres, Marcos, Lecona, Emilio, Fernandez‐Capetillo, Oscar
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2021
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167359/
https://ncbi.nlm.nih.gov/pubmed/33856059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899692
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