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Replication stress and cancer: it takes two to tango

Problems arising during DNA replication require the activation of the ATR-CHK1 pathway to ensure the stabilization and repair of the forks, and to prevent the entry into mitosis with unreplicated genomes. Whereas the pathway is essential at the cellular level, limiting its activity is particularly d...

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Publicat a:Exp Cell Res
Autors principals: Lecona, Emilio, Fernández-Capetillo, Oscar
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878650/
https://ncbi.nlm.nih.gov/pubmed/25257608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2014.09.019
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