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USP7 limits CDK1 activity throughout the cell cycle
Chemical inhibitors of the deubiquitinase USP7 are currently being developed as anticancer agents based on their capacity to stabilize P53. Regardless of this activity, USP7 inhibitors also generate DNA damage in a p53‐independent manner. However, the mechanism of this genotoxicity and its contribut...
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| Udgivet i: | EMBO J |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8167359/ https://ncbi.nlm.nih.gov/pubmed/33856059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899692 |
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