The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13

Dendritic cells (DCs) are indispensable for defense against pathogens but may also contribute to immunopathology. Activation of DCs upon the sensing of pathogens by Toll-like receptors (TLRs) is largely mediated by pattern recognition receptor/nuclear factor-κB (NF-κB) signaling and depends on the a...

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Veröffentlicht in:Cell Mol Immunol
Hauptverfasser: Mulas, Floriana, Wang, Xu, Song, Shanshan, Nishanth, Gopala, Yi, Wenjing, Brunn, Anna, Larsen, Pia-Katharina, Isermann, Berend, Kalinke, Ulrich, Barragan, Antonio, Naumann, Michael, Deckert, Martina, Schlüter, Dirk
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167118/
https://ncbi.nlm.nih.gov/pubmed/32024978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-020-0362-6
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