OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation

In bacterial and sterile inflammation of the liver, hepatocyte apoptosis is, in contrast to necroptosis, a common feature. The molecular mechanisms preventing hepatocyte necroptosis and the potential consequences of hepatocyte necroptosis are largely unknown. Apoptosis and necroptosis are critically...

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Veröffentlicht in:Cell Death Differ
Hauptverfasser: Koschel, Josephin, Nishanth, Gopala, Just, Sissy, Harit, Kunjan, Kröger, Andrea, Deckert, Martina, Naumann, Michael, Schlüter, Dirk
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8257688/
https://ncbi.nlm.nih.gov/pubmed/33712742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-021-00752-9
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