(Pro)renin receptor antagonist PRO20 attenuates nephrectomy‐induced nephropathy in rats via inhibition of intrarenal RAS and Wnt/β‐catenin signaling

INTRODUCTION: (Pro)renin receptor has emerged as a new member of the renin‐angiotensin system implicated in the pathogenesis of chronic kidney disease (CKD). Herein we report characterization of the therapeutic potential of (pro)renin receptor (PRR) antagonist PRO20 in 5/6 nephrectomy (5/6Nx) rats....

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Bibliografske podrobnosti
izdano v:Physiol Rep
Main Authors: Wang, Yan, Wang, Yurong, Xue, Kai, Wang, Huaijie, Zhou, Jingjing, Gao, Feng, Li, Chengde, Yang, Tianxin, Fang, Hui
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2021
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8165733/
https://ncbi.nlm.nih.gov/pubmed/34057312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14881
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