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(Pro)renin Receptor Is an Amplifier of Wnt/β-Catenin Signaling in Kidney Injury and Fibrosis

The (pro)renin receptor (PRR) is a transmembrane protein with multiple functions. However, its regulation and role in the pathogenesis of CKD remain poorly defined. Here, we report that PRR is a downstream target and an essential component of Wnt/β-catenin signaling. In mouse models, induction of CK...

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Bibliografiske detaljer
Udgivet i:J Am Soc Nephrol
Main Authors: Li, Zhen, Zhou, Lili, Wang, Yongping, Miao, Jinhua, Hong, Xue, Hou, Fan Fan, Liu, Youhua
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533230/
https://ncbi.nlm.nih.gov/pubmed/28270411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016070811
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