Klotho Ameliorates Kidney Injury and Fibrosis and Normalizes Blood Pressure by Targeting the Renin-Angiotensin System

Loss of Klotho and activation of the renin-angiotensin system (RAS) are common pathological findings in chronic kidney diseases. However, whether these two events are intricately connected is poorly understood. We hypothesized that Klotho might protect kidneys by targeted inhibition of RAS activatio...

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Bibliografiske detaljer
Udgivet i:Am J Pathol
Main Authors: Zhou, Lili, Mo, Hongyan, Miao, Jinhua, Zhou, Dong, Tan, Roderick J., Hou, Fan Fan, Liu, Youhua
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2015
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729238/
https://ncbi.nlm.nih.gov/pubmed/26475416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.08.004
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